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LETTER TO EDITOR
Year : 2016  |  Volume : 1  |  Issue : 1  |  Page : 35

Incidence of lewis phenotypes and its relation to abo system: A dhaka-based study status of deferred donors during fasting month in bangladesh


1 From the Department of Transfusion Medicine and Hematology, Institute of Research and Rehabilitation of Diabetes, Endocrine and Metabolic Disorders, General Hospital and Ibrahim Medical College, Panthapath, Dhaka-1000, Bangladesh
2 From the Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000, Bangladesh

Date of Web Publication3-Mar-2016

Correspondence Address:
Md Ashadul Islam
From the Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000
Bangladesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2455-8893.178008

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How to cite this article:
Dipta TF, Islam MA. Incidence of lewis phenotypes and its relation to abo system: A dhaka-based study status of deferred donors during fasting month in bangladesh. Glob J Transfus Med 2016;1:35

How to cite this URL:
Dipta TF, Islam MA. Incidence of lewis phenotypes and its relation to abo system: A dhaka-based study status of deferred donors during fasting month in bangladesh. Glob J Transfus Med [serial online] 2016 [cited 2018 Jan 20];1:35. Available from: http://www.gjtmonline.com/text.asp?2016/1/1/35/178008

Sir,

Lewis blood group is unique among major blood group systems.[1],[2]

There was dearth information on Lewis blood grouping on Bangladeshi population, so we studied the frequency of Lewis phenotypes and its relation with ABO system in International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), Dhaka.

This study was done on 350 patients and voluntary blood donors since June 2005 to June 2008. Lewis phenotype had been determined using saliva by hemagglutination technique using monoclonal antibodies (BIOSCOT Ltd., Livingston, UK) as per manufacturer's instruction. Our participants' age range from 1 to 75 years; 50 children (14.3%) were under 5 years; males were 177 (50.6%) and rest was female. Our study findings in [Table 1] showed a positive reaction with Lewis antibody reagents only in 178 (50.8%) cases, whereas negative results reported in 172 (49.2%) subjects. “O” group individuals react more (75%) with anti-Le b reagents and their frequency with ABO system was as follow O > A > AB > B. However, anti-Le a s was predominant in “B” (37.7%) with the frequency of B > AB > A > O. Interestingly, results were comparable to a study done in Bangabandhu Sheikh Mujib Medical University.[3]
Table 1: Incidence of Lewis phenotypes and relation with ABO system in our study

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Clinical significance of Lewis phenotypes and anti-Lewis antibodies: A Dhaka-based study carried out in ICDDR, B showed children with diarrhea had Lewis phenotypes and Le (a+b−) type had significantly higher incidence of enterotoxigenic Escherichia coli diarrhea.[2],[3],[4] Studies showed the presence of Lewis antibody may interferes with interpretation of compatibility test.[5] Hence, our recommendation is, if patients required multiple transfusions or having atypical antibodies, routine test for Lewis blood system should be incorporated to avoid untoward reactions.

Financial Support and Sponsorship

Nil.

Conflicts of Interest

There are no conflicts of interest.

 
  References Top

1.
Knowles SM. Blood cell antigens and antibodies: Erythrocytes, platelets and granulocytes. In: Lewis MS, Bain BJ, Bates I, editors. Dacie and Lewis Practical Haematology. 9th ed. London: Churchill Livingstone; 2001. p. 429-69.  Back to cited text no. 1
    
2.
Arifuzzaman M, Ahmed T, Rahman MA, Chowdhury F, Rashu R, Khan AI, et al. Individuals with Le (a+b−) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection. PLoS Negl Trop Dis 2011;5:e1413.  Back to cited text no. 2
    
3.
Akhter S, Kibria GM, Akhter NR, Habibullah MM, Islam SM, Zakariah M. ABO and Lewis blood grouping with ABH secretor and non-secretor status: A cross sectional study in Dhaka. Faridpur Med Coll J 2011;6:38-40.  Back to cited text no. 3
    
4.
Ahmed T, Lundgren A, Arifuzzaman M, Qadri F, Teneberg S, Svennerholm AM. Children with the Le (a+b−) blood group have increased susceptibility to diarrhea caused by enterotoxigenic Escherichia coli expressing colonization factor I group fimbriae. Infect Immun 2009;77:2059-64.  Back to cited text no. 4
    
5.
D'Adamo PJ, Kelly GS. Metabolic and immunologic consequences of ABH secretor and Lewis subtype status. Altern Med Rev 2001;6:390-405.  Back to cited text no. 5
    



 
 
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