|LETTER TO EDITOR
|Year : 2016 | Volume
| Issue : 1 | Page : 35
Incidence of lewis phenotypes and its relation to abo system: A dhaka-based study status of deferred donors during fasting month in bangladesh
Tashmim Farhana Dipta1, Md Ashadul Islam2
1 From the Department of Transfusion Medicine and Hematology, Institute of Research and Rehabilitation of Diabetes, Endocrine and Metabolic Disorders, General Hospital and Ibrahim Medical College, Panthapath, Dhaka-1000, Bangladesh
2 From the Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000, Bangladesh
|Date of Web Publication||3-Mar-2016|
Md Ashadul Islam
From the Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Dipta TF, Islam MA. Incidence of lewis phenotypes and its relation to abo system: A dhaka-based study status of deferred donors during fasting month in bangladesh. Glob J Transfus Med 2016;1:35
|How to cite this URL:|
Dipta TF, Islam MA. Incidence of lewis phenotypes and its relation to abo system: A dhaka-based study status of deferred donors during fasting month in bangladesh. Glob J Transfus Med [serial online] 2016 [cited 2018 Apr 26];1:35. Available from: http://www.gjtmonline.com/text.asp?2016/1/1/35/178008
Lewis blood group is unique among major blood group systems.,
There was dearth information on Lewis blood grouping on Bangladeshi population, so we studied the frequency of Lewis phenotypes and its relation with ABO system in International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), Dhaka.
This study was done on 350 patients and voluntary blood donors since June 2005 to June 2008. Lewis phenotype had been determined using saliva by hemagglutination technique using monoclonal antibodies (BIOSCOT Ltd., Livingston, UK) as per manufacturer's instruction. Our participants' age range from 1 to 75 years; 50 children (14.3%) were under 5 years; males were 177 (50.6%) and rest was female. Our study findings in [Table 1] showed a positive reaction with Lewis antibody reagents only in 178 (50.8%) cases, whereas negative results reported in 172 (49.2%) subjects. “O” group individuals react more (75%) with anti-Le b reagents and their frequency with ABO system was as follow O > A > AB > B. However, anti-Le a s was predominant in “B” (37.7%) with the frequency of B > AB > A > O. Interestingly, results were comparable to a study done in Bangabandhu Sheikh Mujib Medical University.
|Table 1: Incidence of Lewis phenotypes and relation with ABO system in our study|
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Clinical significance of Lewis phenotypes and anti-Lewis antibodies: A Dhaka-based study carried out in ICDDR, B showed children with diarrhea had Lewis phenotypes and Le (a+b−) type had significantly higher incidence of enterotoxigenic Escherichia coli diarrhea.,, Studies showed the presence of Lewis antibody may interferes with interpretation of compatibility test. Hence, our recommendation is, if patients required multiple transfusions or having atypical antibodies, routine test for Lewis blood system should be incorporated to avoid untoward reactions.
Financial Support and Sponsorship
Conflicts of Interest
There are no conflicts of interest.
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