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CASE REPORT
Year : 2019  |  Volume : 4  |  Issue : 1  |  Page : 105-107

A successful pregnancy occurred after isolating the offending antibody(s) and choosing appropriate sperm donor of similar phenotype


1 Department of Immunohaematology and Blood Transfusion, Medical College and Hospital, Kolkata, West Bengal, India
2 Transfusion Centre Eastern Command, Kolkata, West Bengal, India
3 Department of Blood Bank, AMRI Hospitals, Kolkata, West Bengal, India

Correspondence Address:
Dr. Prasun Bhattacharya
Department of Immunohaematology and Blood Transfusion, Medical College and Hospital, Kolkata, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/GJTM.GJTM_55_18

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Sensitization against Rh(D )is the most common cause of haemolytic disease of fetus and newborn (HDFN). Now a days, a widespread use of antenatal and postnatal Rh immunoglobulin has resulted in marked decrease in prevalence of Rh(D) alloimmunization. Fetal loss due to other red cell antigens gain importance as there are no prophylactic immunoglobulin are available. Here, we present a case of primary infertility associated with non Rh(D) alloimmunization which was detected in a 30 year old housewife during her ongoing infertility treatment. The antibody identification workup showed patient is having multiple alloantibodies , probable anti-c, and anti-Fya. The extended phenotype shows that the husband is mismatched with the wife's phenotype in “c” and Fya. Also the probable antibody in the mother's serum are anti-c and anti-Fya which are noted to cause HDFN as per literature.


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