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 Table of Contents  
LETTERS TO EDITOR
Year : 2019  |  Volume : 4  |  Issue : 1  |  Page : 119-120

Association with ABO blood group with olfactory function


Department of Pathology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India

Date of Web Publication22-Apr-2019

Correspondence Address:
Dr. Subhashish Das
Department of Pathology, Sri Devaraj Urs Medical College, Kolar, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/GJTM.GJTM_53_18

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How to cite this article:
Das S. Association with ABO blood group with olfactory function. Glob J Transfus Med 2019;4:119-20

How to cite this URL:
Das S. Association with ABO blood group with olfactory function. Glob J Transfus Med [serial online] 2019 [cited 2019 Nov 15];4:119-20. Available from: http://www.gjtmonline.com/text.asp?2019/4/1/119/256769



Sir,

The clinical significance of the ABO blood group system extends beyond transfusion medicine and several reports have suggested an important involvement in the development of cardiovascular, oncological, and other diseases.[1]

Along with their expression on red blood cells, ABO antigens are also highly expressed on the surface of a variety of human cells and tissues, including the epithelium, sensory neurons, platelets, and the vascular endothelium.[2]

Recent research has also carved out a role for ABO blood group antigens in neuroscience. In fact, these antigens have been implicated in the development of olfactory nerve connectivity. In 1985, Mollicone et al. described the expression of B and H antigens on primary sensory cells of the rat olfactory apparatus and inner ear.[3] Villarroya et al. suggested a possible role of the A gene or a gene closely linked to the ABO locus in the differential susceptibility to experimental allergic encephalomyelitis in rabbits.[4] Another study, a further study demonstrated that the histo-blood group H carbohydrate is expressed by primary sensory neurons in both the main and accessory olfactory systems while the blood group A carbohydrate is expressed by a subset of vomeronasal neurons in the developing accessory olfactory system.[5] This study showed that blood group sugars are involved in axon guidance events in the developing olfactory systems. A more recent report also provided evidence that the cell surface carbohydrate blood group A regulates the selective fasciculation of regenerating accessory olfactory axons.[5]

Although blood group is not proximally associated with olfactory function of an individual more detail study and invasive study in controlled environment having adequate sample size are needed to reach a definite conclusion.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Franchini M, Capra F, Targher G, Montagnana M, Lippi G. Relationship between ABO blood group and von willebrand factor levels: From biology to clinical implications. Thromb J 2007;5:14.  Back to cited text no. 1
    
2.
Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci 2012;49:137-49.  Back to cited text no. 2
    
3.
Mollicone R, Trojan J, Oriol R. Appearance of H and B antigens in primary sensory cells of the rat olfactory apparatus and inner ear. Brain Res 1985;349:275-9.  Back to cited text no. 3
    
4.
Villarroya H, Dalix AM, Paraut M, Oriol R. Differential susceptibility to experimental allergic encephalomyelitis (EAE) in genetically defined A+ and A– Rabbits. Autoimmunity 1990;6:47-60.  Back to cited text no. 4
    
5.
St John JA, Claxton C, Robinson MW, Yamamoto F, Domino SE, Key B, et al. Genetic manipulation of blood group carbohydrates alters development and pathfinding of primary sensory axons of the olfactory systems. Dev Biol 2006;298:470-84.  Back to cited text no. 5
    




 

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