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Year : 2019  |  Volume : 4  |  Issue : 1  |  Page : 87-89

Oblivious of the yellow world – A newborn's telltale: ABO hemolytic disease of newborn

1 Department of Transfusion Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
2 Department of Neonatology, Max Superspecialty Hospital, New Delhi, India
3 Department of Paediatrics, Max Superspecialty Hospital, New Delhi, India

Correspondence Address:
Dr. Daljit Kaur
Department of Transfusion Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/GJTM.GJTM_45_18

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The increased destruction of fetal red cells can be immune (allo- or autoantibodies) or nonimmune (hemoglobinopathies, enzyme defects, and membrane defects) in nature and can cause shortened life span of red cells leading to hemolytic disease of the fetus and newborn. Maternofetal ABO incompatibility is common but rarely leads to severe anemia due to poorly developed A or B antigens on fetal red blood cells and neutralization of antibody by tissue and soluble ABO blood group substances in plasma, while RhD hemolytic disease of newborn (HDN) occurring due to D-antigen sensitization in D-negative mothers may lead to severe HDN. Here, we report a case of an inborn neonate who was admitted in neonatal intensive care unit of our hospital at day 1 of life with severe hyperbilirubinemia and needed exchange transfusion.

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