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CASE REPORT
Year : 2019  |  Volume : 4  |  Issue : 2  |  Page : 234-236

A case report of neonatal alloimmune thrombocytopenia: The utility of platelet crossmatch studies in the diagnosis and management


1 Department of Neonatology, Manipal Hospital, Bengaluru, Karnataka, India
2 Department of Transfusion Medicine, Manipal Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Dr. H A Venkatesh
Department of Neonatology, Manipal Hospital, Bengaluru, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/GJTM.GJTM_50_19

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Alloimmune thrombocytopenia is the most common cause of severe thrombocytopenia and intracranial bleed in the perinatal period, resulting from placental transfer of maternal platelet antibodies directed against the paternal-derived fetal platelet antigens. It is estimated to occur in 1 in 2500 births but continues to be an underdiagnosed and underreported condition in our country. Detection of human platelet antigen-specific antibody in the maternal serum and platelet genotyping are the gold standards in the diagnosis. This case report highlights the utility of platelet crossmatch studies in the diagnosis and management of neonatal alloimmune thrombocytopenia.


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