|Year : 2020 | Volume
| Issue : 1 | Page : 111-112
The role of serum kerbs von lungren 6 antigen in transfusion-related acute lung injury
Wang Gui-Qiang, Lin Xin-Mei, Feng Jun-Jian, Zhang Li, Wei Mao-Hua
Department of Critical Care Medicine; Department of Blood Transfusion, Luzhou People's Hospital, Luzhou, China
|Date of Submission||01-Apr-2020|
|Date of Decision||01-Apr-2020|
|Date of Acceptance||01-Apr-2020|
|Date of Web Publication||17-Apr-2020|
Department of Critical Care Medicine; Department of Blood Transfusion, Luzhou People's Hospital, Luzhou
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Gui-Qiang W, Xin-Mei L, Jun-Jian F, Li Z, Mao-Hua W. The role of serum kerbs von lungren 6 antigen in transfusion-related acute lung injury. Glob J Transfus Med 2020;5:111-2
|How to cite this URL:|
Gui-Qiang W, Xin-Mei L, Jun-Jian F, Li Z, Mao-Hua W. The role of serum kerbs von lungren 6 antigen in transfusion-related acute lung injury. Glob J Transfus Med [serial online] 2020 [cited 2020 Aug 11];5:111-2. Available from: http://www.gjtmonline.com/text.asp?2020/5/1/111/282733
| Introduction|| |
Kerbs von Lungren 6 antigen (KL-6) is mainly secreted by proliferative, stimulated, or damaged alveolar epithelial type II cell. At present, KL-6 has been used as a serological indicator related to alveolar injury and severity in many respiratory diseases. Transfusion-related acute lung injury (TRALI) is a clinical syndrome characterized by acute noncardiogenic pulmonary edema and hypoxemia that occurs within 6 h after the transfusion. The pathogenesis of TRALI may involve the damage of alveolar epithelial cells and changes in alveolar capillary permeability. There are few reports on whether KL-6 can be used as a serological marker for the diagnosis of TRALI.
| Methods|| |
In this study, we prospectively analyzed clinical, radiological, and laboratory data of a cohort of 95 patients supported by mechanical ventilation. All the data were collected before transfusion and at the time of 6 h after transfusion, including plasma BNP levels, arterial blood gas analysis, bedside chest X-ray examination, ventilator parameters, Murray lung injury score, and serum KL-6 levels. Ninety-five patients were categorized into TRALI group and non-TRALI group according to the criteria of TRALI. Serum KL-6 level was determined by enzyme-linked immunosorbent assay method. We compared the change of serum KL-6 levels between the TRALI group and non-TRALI group, analyzed the correlation between serum KL-6 and Murray lung injury score, and oxygenation index. We further evaluated the diagnostic value of serum KL-6 using ROC curve for diagnosing TRALI.
|Figure 1: Correlation analysis between serum kl-6 level and Murray lung injury score|
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| Results|| |
All the indexes, including Murray lung injury score, plat pressure (Pplat), peak pressure (Ppeak), oxygenation index, serum KL-6 level, and BNP level, showed no significant differences between TRALI group and non-TRALI group before transfusion (P > 0.05). In TRALI group, we found much higher serum KL-6 level, Murray lung injury score, Ppeak, and Pplat and lower oxygenation at the time of 6 h after transfusion compared with baseline (P < 0.05). There was no significant difference in non-TRALI group. Compared with non-TRALI group, we found much higher serum KL-6 level, Murray lung injury score, Ppeak, and Pplat and lower oxygenation at the time of 6 h after transfusion (P < 0.05). Serum KL-6 level showed a positive correlation with lung injury score (correlation coefficient was 0.811, P < 0.001). Serum KL-6 level showed a negative correlation with the oxygenation index (correlation coefficient was 0.680, P < 0.001). ROC curve analysis showed that serum KL-6 level could be used for diagnosing TRALI, and the area under the curve was 0.966, P < 0.001. The sensitivity and specificity were 85.0% and 97.4%, respectively, when the level of serum KL-6 was higher than 369 U/ml.
|Figure 2: Correlation analysis between serum KL-6 level and oxygenation index|
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| Discussion and Conclusion|| |
In our study, the results indicated when TRALI occurred in susceptible patients, damaged alveolar epithelial cells increased the expression of KL-6, and impairment of lung capillary permeability induced the increase of serum KL-6. In conclusion, serum KL-6 was a serological marker for acute lung injury, which might be helpful for TRALI diagnosis and severity evaluation of the patients with mechanical ventilation.
For detailed article log on to: Journal of Clinical Transfusion and Lab Medicine http://www.lcsxyjy.com/CN/10.3969/j.issn. 1671-2587.2019.05.001.
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Conflicts of interest
There are no conflicts of interest.
[Figure 1], [Figure 2]