A case of naturally occurring anti-E mimicking anti-A1

Vinu Rajendran; Revathy Nair; AP Poornima; Debasish Gupta

doi:10.4103/GJTM.GJTM_23_20

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CASE REPORT

Year : 2020 | Volume : 5 | Issue : 2 | Page : 228-229

A case of naturally occurring anti-E mimicking anti-A1

Vinu Rajendran¹, Revathy Nair², AP Poornima³, Debasish Gupta⁴
¹ Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India
² Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
³ Department of Transfusion Medicine, Government Medical College, Kollam, Kerala, India
⁴ Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India

Correspondence Address:
Vinu Rajendran
Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/GJTM.GJTM_23_20

Rhesus (Rh) antibodies are usually of the acquired IgG type. Naturally occurring IgM type of Rh antibody is unusual. We report a case of naturally occurring IgM anti-E which mimicked anti-A1. ABO grouping of a 61-year-old man posted for surgery showed discrepancy. Cell group corresponded to A positive while reverse grouping showed weak agglutination with A cells. Nonreactivity of red cells with A1 lectin suggested the possibility of A subgroup with anti-A1. Anti-A1 was ruled out on further testing of serum with A1-positive red cells. Antibody screening and identification revealed the presence of anti-E. The presence of Rh E antigen in the reagent A cell was the reason for weak agglutination. Antibody titer of 4 and 2 was observed at 4°C and 37°C incubation, respectively, in the untreated serum. Antibody was undetectable in the dithiothreitol-treated serum both at 4°C and 37°C confirming the IgM nature of the antibody.

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