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 Table of Contents  
SPECIAL COMMUNICATION
Year : 2020  |  Volume : 5  |  Issue : 2  |  Page : 237-239

Changes in autologous blood of late pregnancy women during preservation


Department of Transfusion, Affiliated Hospital of Qingdao University, Qingdao, China

Date of Submission21-Oct-2020
Date of Decision21-Oct-2020
Date of Acceptance21-Oct-2020
Date of Web Publication13-Nov-2020

Correspondence Address:
Wang Hai-Yan
Department of Transfusion, Affiliated Hospital of Qingdao University, Qingdao
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2468-8398.300646

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How to cite this article:
Xiao-Yuan S, Hai-Yan W. Changes in autologous blood of late pregnancy women during preservation. Glob J Transfus Med 2020;5:237-9

How to cite this URL:
Xiao-Yuan S, Hai-Yan W. Changes in autologous blood of late pregnancy women during preservation. Glob J Transfus Med [serial online] 2020 [cited 2020 Nov 26];5:237-9. Available from: https://www.gjtmonline.com/text.asp?2020/5/2/237/300646

This special communication is reproduced with permission from Journal of Clinical Transfusion and Lab Medicine





  Introduction Top


Preoperative autologous blood donation (PABD) refers to the blood transfusion method in which patients' self-blood is collected, processed, and preserved before surgery or delivery, and then issued to themselves when necessary. PABD can significantly reduce adverse events such as hemolytic reaction, transfusion-related infectious diseases, and immune-mediated complications and reduce the usage of allogeneic blood. Due to the unpredictability of delivery, PABD is also playing an accident insurance role for pregnant women with rare blood group or unexpected antibodies. The blood of pregnant women in late pregnancy has special physiological and biochemical characteristics. Our study aimed to investigate the changes of autologous whole blood during the preservation in the third trimester of pregnancy and to provide theoretical guidance for PABD in pregnant women.


  Methods Top


Twenty-eight late pregnancy women with autologous blood storage in transfusion department of our hospital were enrolled and divided equally into routine anticoagulant group (Group 1) and high-anticoagulant group (Group 2). At the same time, twenty cases of routine anti-coagulated female unpaid blood were selected as controls. Then, the changes of blood coagulation function, blood viscosity, lactic acid concentration, blood potassium, and blood appearance in three groups during preservation were monitored and the utilization rate of autologous blood in the obstetric group was measured.


  Results Top


The prothrombin time (PT) and activated partial thromboplastin time (APTT) values of Group 1 were statistically significantly lower than that of control (P < 0.05), and fibrinogen (FIB) concentration was statistically significantly higher than that of control (P < 0.01) at 1 h after collection [Table 1] and [Figure 1]. During the preservation, compared with the control group, the APTT value and PT value of Group 1 had gradually prolonged (P < 0.05) [Table 2]; erythrocyte aggregation index value [Table 3], blood potassium, and lactic acid concentration had gradually increased (P < 0.05); and FIB concentration had gradually decreased (P < 0.05), but there was no significant difference between Group 2 and control group (P > 0.05). The blood of Group 1 women showed fine particle agglutination on the 3rd day. There were 18, 11, and 10 bags of blood which showed particle agglutination phenomenon in Group 1, Group 2, and control group, respectively, on the 35th day. The utilization rate of preoperative autologous blood in obstetric group was 3.6% (1/28).
Table 1: Comparison of coagulation function in obstetric group and control group at 1 h after blood collection

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Figure 1: Changes of coagulation function during blood preservation

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Table 2: Changes of coagulation function during blood preservation

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Table 3: Changes of the red cell aggregation index during blood preservation

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  Conclusion Top


The blood of pregnant women in the third trimester is hypercoagulable. Conventional anticoagulated whole blood undergoes a change in blood quality during storage, manifested by increased lactic acid production, potassium concentration, and blood viscosity, micro agglutination had occurred on the 3rd day [Figure 2], [Figure 3] and [Table 4]. Increased proportion of anticoagulant during blood preservation can effectively solve this problem.
Figure 2: Changes of blood viscosity during blood preservation

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Figure 3: Changes of lactic acid and blood potassium during blood preservation

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Table 4: Changes of lactic acid and blood potassium during blood preservation

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For detailed article, log on to: Journal of Clinical Transfusion and Lab Medicine Available from: http://www.lcsxyjy.com/CN/10.3969/j. issn. 1671-2587.2020.03.010

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.




    Figures

  [Figure 1], [Figure 2], [Figure 3]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]



 

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