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ORIGINAL ARTICLE
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An analysis of association of human leukocyte antigen and liver disease patients in a tertiary care hospital, India


1 Department Of Transfusion Medicine, Molecular and Transplant Immunology Laboratory, Medanta - The Medicity, Gurgaon, Haryana, India
2 Department of Digestive and Hepatobiliary Sciences, Medanta - The Medicity, Gurgaon, Haryana, India
3 Department of Liver Transplant and Regenerative Medicine, Medanta - The Medicity, Gurgaon, Haryana, India

Correspondence Address:
Simmi Mehra,
Department Of Transfusion Medicine, Molecular and Transplant Immunology Laboratory, Medanta - The Medicity, Gurgaon, Haryana
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/GJTM.GJTM_46_20

Background and Objectives: In addition, the role of human leukocyte antigen (HLA) in transplantation, importance of HLA in disease susceptibility, and protection has been widely studied. The aim of the present study was to find out the HLA allelic frequency (HLA-A,-B,-DRB1) and its association with liver diseases. Methods: The present study was done for the duration of 4 years from 2013 to 2017 in a tertiary care center which primarily caters to north Indian patient population. A total of 429 patients were studied. The HLA genotyping was performed by molecular method using commercial available low resolution ABDR sequence-specific oligonucleotide probe-based method (Luminex platform). Results: There was an increased association of HLA-A*01 (n = 9, 18.6%), HLA-B*15, B*35, B*40, B*44 (n = 5, 11.6%), and HLA-DRB1*15 (n = 9, 20.9%) in 43 patients with hepatitis B virus (HBV)-related disease. There was an increased association of HLA-A*24 (n = 9, 20.7%), HLA-B*35, B*40 (n = 14, 15.2%), and HLA-DRB1*15 (n = 17, 18.5%) in 92 patients with alcohol-related disease. An increased association of HLA-A*11 (n = 30, 19.6%), HLA-B*35 (n = 24, 16.8%) and HLA-DRB1*15 (n = 28, 19.6%) in 143 patients with hepatitis C virus (HCV) related disease. Conclusion: This is possibly the first study in the north Indian patients having liver diseases related to HBV, HCV, and alcohol related with respect to A, B, and DR loci previous studies from India were conducted to see disease association of HLA class I and class II with respect to HCV only.


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