Global Journal of Transfusion Medicine

CASE REPORT
Year
: 2019  |  Volume : 4  |  Issue : 2  |  Page : 231--233

Anti-D antibody in a D-positive patient: Autoantibody or development of alloantibody after platelet transfusion


Sadhana Mangwana, Vivek Gangwar 
 Department of Transfusion Medicine, Sri Balaji Action Medical Institute, New Delhi, India

Correspondence Address:
Dr. Sadhana Mangwana
Department of Transfusion Medicine, Sri Balaji Action Medical Institute, New Delhi
India

Rh D (D or RH 1) is next clinically important blood group after ABO blood group system. Although most people are either D+ or D−, there are a large number of individuals having different forms of D variants; weak D, partial D, or DEL phenotypes. We present a case report of a 32-year-old male with a history of cough and cold for 5 days with development of petechial rashes all over the body from day 1 and afebrile and marked thrombocytopenia. He was transfused with multiple platelet concentrates. Initially, there was an absence of irregular red cell antibodies, but after 72 h of transfusion, he developed autoanti-D antibody. An accurate D-antigen identification is important and essential for pretransfusion evaluation to prevent antibody formation, and a partial D variant might be suspected when typing for the D antigen showing weaker-than-normal reactions. This case emphasizes that some partial D variants are likely to be missed by routine serological tests.


How to cite this article:
Mangwana S, Gangwar V. Anti-D antibody in a D-positive patient: Autoantibody or development of alloantibody after platelet transfusion.Glob J Transfus Med 2019;4:231-233


How to cite this URL:
Mangwana S, Gangwar V. Anti-D antibody in a D-positive patient: Autoantibody or development of alloantibody after platelet transfusion. Glob J Transfus Med [serial online] 2019 [cited 2021 Dec 2 ];4:231-233
Available from: https://www.gjtmonline.com/article.asp?issn=2468-8398;year=2019;volume=4;issue=2;spage=231;epage=233;aulast=Mangwana;type=0