Global Journal of Transfusion Medicine

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 5  |  Issue : 2  |  Page : 135--138

Accelerated hepatitis B vaccination: Efficacy in young, regular blood donors


Maryam Zadsar1, Esmail Sanei Moghaddam2, Seyed Moayed Alavian3, Fariba Seighali1 
1 Research Center, High Institute of Education and Research in Transfusion Medicine, Tehran, Iran
2 Iranian Blood Transfusion Organization Research Center, High Institute of Education and Research in Transfusion Medicine, Zahedan, Iran
3 Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences; Middle East Liver Diseases Research Center; Iran Hepatitis Network, Tehran, Iran

Correspondence Address:
Fariba Seighali
Research Center, High Institute of Education and Research in Transfusion Medicine, Tehran
Iran

Background and Objectives: Hepatitis B (HB) – a vaccine-preventable, transfusion-transmitted infection – has been estimated to have high residual risk, especially in medium- and high-endemic areas. This potent immunogenic vaccine is routinely injected at 0, 1, and 6 months. Accelerated schedule has been recommended in adults to increase the completion rate. We studied the response rate of accelerated schedule in young, regular blood donors in a high-prevalence area for HB virus (HBV) in Iran. Methods: Young, regular nonimmunized blood donors were vaccinated with recombinant DNA HB surface antigen vaccine (Pasteur Institute of Iran) containing 20 μg of material in 1-ml solution injected intramuscularly to the deltoid muscle at 0, 1, and 2 months. HB surface antibody (HBsAb) was titered 1 month after the completion of doses. Nonresponders took one additional dose and tested a month later. Results: A total of 357 donors with a mean age of 26 ± 3.5 years were enrolled, of whom 287 donors completed three doses of vaccination (80% adherence rate). HBsAb titer was >10 IU/ml in 274 donors (95.5% response rate), whereas after one booster dose injection, the titer in 13 nonresponder persons (4.5%) increased to >10 IU/ml. Conclusion: Accelerated HBV vaccination with near 100% response rate and 80% adherence rate in young, regular blood donors has been successful in the immunization of young blood donors. This strategy improves not only blood safety but also donors' health.


How to cite this article:
Zadsar M, Moghaddam ES, Alavian SM, Seighali F. Accelerated hepatitis B vaccination: Efficacy in young, regular blood donors.Glob J Transfus Med 2020;5:135-138


How to cite this URL:
Zadsar M, Moghaddam ES, Alavian SM, Seighali F. Accelerated hepatitis B vaccination: Efficacy in young, regular blood donors. Glob J Transfus Med [serial online] 2020 [cited 2021 Apr 13 ];5:135-138
Available from: https://www.gjtmonline.com/article.asp?issn=2468-8398;year=2020;volume=5;issue=2;spage=135;epage=138;aulast=Zadsar;type=0