Global Journal of Transfusion Medicine

: 2020  |  Volume : 5  |  Issue : 2  |  Page : 237--239

Changes in autologous blood of late pregnancy women during preservation

Sun Xiao-Yuan, Wang Hai-Yan 
 Department of Transfusion, Affiliated Hospital of Qingdao University, Qingdao, China

Correspondence Address:
Wang Hai-Yan
Department of Transfusion, Affiliated Hospital of Qingdao University, Qingdao

How to cite this article:
Xiao-Yuan S, Hai-Yan W. Changes in autologous blood of late pregnancy women during preservation.Glob J Transfus Med 2020;5:237-239

How to cite this URL:
Xiao-Yuan S, Hai-Yan W. Changes in autologous blood of late pregnancy women during preservation. Glob J Transfus Med [serial online] 2020 [cited 2021 Jul 26 ];5:237-239
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Full Text


Preoperative autologous blood donation (PABD) refers to the blood transfusion method in which patients' self-blood is collected, processed, and preserved before surgery or delivery, and then issued to themselves when necessary. PABD can significantly reduce adverse events such as hemolytic reaction, transfusion-related infectious diseases, and immune-mediated complications and reduce the usage of allogeneic blood. Due to the unpredictability of delivery, PABD is also playing an accident insurance role for pregnant women with rare blood group or unexpected antibodies. The blood of pregnant women in late pregnancy has special physiological and biochemical characteristics. Our study aimed to investigate the changes of autologous whole blood during the preservation in the third trimester of pregnancy and to provide theoretical guidance for PABD in pregnant women.


Twenty-eight late pregnancy women with autologous blood storage in transfusion department of our hospital were enrolled and divided equally into routine anticoagulant group (Group 1) and high-anticoagulant group (Group 2). At the same time, twenty cases of routine anti-coagulated female unpaid blood were selected as controls. Then, the changes of blood coagulation function, blood viscosity, lactic acid concentration, blood potassium, and blood appearance in three groups during preservation were monitored and the utilization rate of autologous blood in the obstetric group was measured.


The prothrombin time (PT) and activated partial thromboplastin time (APTT) values of Group 1 were statistically significantly lower than that of control (P < 0.05), and fibrinogen (FIB) concentration was statistically significantly higher than that of control (P < 0.01) at 1 h after collection [Table 1] and [Figure 1]. During the preservation, compared with the control group, the APTT value and PT value of Group 1 had gradually prolonged (P < 0.05) [Table 2]; erythrocyte aggregation index value [Table 3], blood potassium, and lactic acid concentration had gradually increased (P < 0.05); and FIB concentration had gradually decreased (P < 0.05), but there was no significant difference between Group 2 and control group (P > 0.05). The blood of Group 1 women showed fine particle agglutination on the 3rd day. There were 18, 11, and 10 bags of blood which showed particle agglutination phenomenon in Group 1, Group 2, and control group, respectively, on the 35th day. The utilization rate of preoperative autologous blood in obstetric group was 3.6% (1/28).{Table 1}{Figure 1}{Table 2}{Table 3}


The blood of pregnant women in the third trimester is hypercoagulable. Conventional anticoagulated whole blood undergoes a change in blood quality during storage, manifested by increased lactic acid production, potassium concentration, and blood viscosity, micro agglutination had occurred on the 3rd day [Figure 2], [Figure 3] and [Table 4]. Increased proportion of anticoagulant during blood preservation can effectively solve this problem.{Figure 2}{Figure 3}{Table 4}

For detailed article, log on to: Journal of Clinical Transfusion and Lab Medicine Available from: issn. 1671-2587.2020.03.010

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Conflicts of interest

There are no conflicts of interest.